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Study warns of serious risks associated with weight loss drugs

October 8, 2023
in Lifestyle
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A brand new examine suggests that folks taking common injectable weight reduction drugs, together with Wegovy and Ozempic, could also be vulnerable to severe issues.

In a analysis letter revealed within the Journal of the American Medical Affiliation (JAMA), College of British Columbia researchers famous that the people could also be extra prone to develop extreme digestive issues reminiscent of abdomen paralysis, pancreatitis, and bowel obstructions than those that take different weight reduction drugs, CNN reported.

The researchers’ findings had been obtained by filtering via a random pattern of greater than 16 million insurance coverage claims from a broad prescription drug database filed between 2006 and 2020.

The US Meals and Drug Administration licensed semaglutide, or Ozempic and Wegovy, in 2021 for overweight sufferers who don’t have diabetes and have to shed weight. (Photograph Credit score: Adobe Inventory)

Whereas the likelihood of the issues occurring in people seemed to be low, researchers contend that demand for the drugs has skyrocketed, with tens of thousands and thousands utilizing them globally.

They added that even unusual dangers may end in tons of of hundreds of further instances.

“When you will have thousands and thousands of individuals utilizing these medication, , a 1% threat nonetheless interprets to many individuals who might expertise these occasions,” stated lead examine writer Dr. Mahyar Etminan, an epidemiologist on the College of British Columbia.

Researchers regarded for sufferers who obtained two injectable drugs, semaglutide (injected weekly) and liraglutide (a every day injectable). The medicines are GLP-1 agonists, which delay the transit of meals via the abdomen. 

They might help folks with diabetes regulate their blood sugar and result in important weight reduction for these with or with out diabetes.

The U.S. Meals and Drug Administration licensed semaglutide in 2021 for overweight sufferers who don’t have diabetes and have to shed weight. It’s marketed as Ozempic when it is suggested for diabetes and Wegovy when used for weight discount.

Ozempic? Wegovy? Mounjaro? Here’s the skinny on the latest weight loss drug craze.

The prescribing data for Wegovy warns about a number of severe negative effects, together with pancreatic irritation, gallbladder and kidney issues, blocked intestines, extreme allergic reactions, elevated coronary heart price, suicidal ideas and imaginative and prescient adjustments in folks with diabetes. 

A warning for ileus, or obstructed intestines, was additionally just lately added to Ozempic’s warning label. In accordance with the labeling, essentially the most prevalent hostile results embrace nausea, vomiting and constipation.

In absolute phrases, the group receiving Ozempic had a virtually 1% price of recent occurrences of abdomen paralysis. Researchers found no bowel blockages within the Ozempic group, and there was a 0.5% threat of pancreatitis.

There have been 4 incidences of gastroparesis or abdomen paralysis among the many 600 sufferers utilizing Ozempic, two instances of pancreatitis, no bowel blockages, and 5 cases of biliary sickness.

The analysis up to now has limitations, together with that it’s observational and might’t show the medication triggered the identified situations. Moreover, although the researchers solely studied semaglutide and liraglutide, they surmise issues could also be linked to all GLP-1 class drugs. This class consists of tirzepatide, at present marketed because the diabetes remedy Mounjaro and beneath assessment by the FDA for weight reduction, experiences Time journal.

Whereas researchers took steps to attempt to discover people who might need been utilizing the medication for weight reduction, there isn’t any certain option to verify why they had been injecting them.

Nonetheless, that is the primary time researchers have been capable of put numbers to those dangers. Specialists who weren’t concerned within the examine stated it was properly carried out however has some limits and gained’t be the ultimate phrase.

Where do Black people fit into the Ozempic conversation?

Researchers hope their examine will assist folks make extra knowledgeable drug choices and that regulatory companies and drug makers will contemplate updating their merchandise’ warning labels, which at present don’t embrace the hazard of gastroparesis. Time experiences that on Sept. 28, the U.S. Meals and Drug Administration (FDA) “requested producers of semaglutide medication to incorporate a warning within the remedy label concerning the doable threat of intestinal blockage, after receiving 8,500 experiences of the situation from each diabetic and non-diabetic customers.”

Ozempic producer Novo Nordisk stated it stands behind the security and effectiveness of all its GLP-1 drugs when used accurately.

“With respect to the examine, because the authors acknowledge, the examine has limitations, together with potential confounding by indication and by different elements,” the corporate stated, CNN reported.

The producer really helpful sufferers take their drugs for his or her authorized indications, including, “Remedy choices needs to be made along with a healthcare supplier who can consider the appropriateness of utilizing a GLP-1 primarily based on evaluation of a affected person’s particular person medical profile.”

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